Abstract

DE LA PORTILLA TERESA-CALLEJA, Tahumara; ANIAS CALDERON, José; CHAO GONZALEZ, Susana  and  RIO VAZQUEZ, Vicente. Effect of sleep deprivation on the blood pressure of rats. Rev Cubana Invest Bioméd [online]. 2009, vol.28, n.2, pp. 0-0. ISSN 1561-3011.

With the objective of evaluating the effects of chronic sleep deprivation on the systolic blood pressure, three groups of 8 Wistar rats were studied- a control group with no sleep deprivation and two experimental groups subjected to total sleep deprivation and MOR sleep phase deprivation, respectively- for continuous 96h periods weekly throughout 2 months. Systolic blood pressure was taken in all the three groups every week before starting the sleep deprivation period. After two months, their kidneys were extracted. The results yielded that there was a statistically significant difference between the control group and the group subjected to total sleep deprivation. As to the histological study of the kidney cuts, nephrosclerosis alterations were not found. In the study model the total sleep deprivation brings about a remarkable rise in systolic blood pressure, except for the group which underwent MOR sleep phase deprivation and that renal morphological alterations does not seem to be involved in hypertension resulting from the applied techniques.

Keywords : Chronic sleep deprivation; systolic blood pressure; total sleep deprivation; MOR sleep phase deprivation; blood hypertension.