Abstract

MIYARES CAO, Carlos Manuel et al. Effectiveness of a Human Placental Extract with Calcium (Melagenina Plus) for the treatment of Vitiligo. Rev Cubana Invest Bioméd [online]. 2009, vol.28, n.3, pp. 9-24. ISSN 1561-3011.

Introduction: Human placental alcohol extract have been successfully used on melanogenesis and melanocyte proliferation. Such extracts cause an increase in the number of melanocytes and melanin granules when applied topically on the ears and tails of black mice. Objectives: Assessment of the effectiveness of a human placental alcohol extract with calcium (Melagenina Plus) for the treatment of vitiligo, since this disease is characterized by melanocyte loss and consequently of melanine pigment. Material and methods: A retrospective study was carried out with 300 cuban vitiligo patients which were chosen because of their correct application on their depigmented areas of the human placental alcohol extract with calcium. Patients selection was made among those involved in the treatment with Melagenina Plus from the Clinical Service of the Placental Histotherapy Center since 1998 to 2003. Results: At the end of the study, 231 patients showed total or marked repigmentation, 28 moderate repigmentation, 24 no repigmentation and 17 new lesions. Conclusions: Results demonstrate that placental alcohol extracts with calcium added can be very effective and innocuous for the vitiligo treatment.

Keywords : treatment; vitiligo; placental.

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