Abstract

CARDENAS SANDOVAL, Rosy Paola; GARZON ALVARADO, Diego Alexander  and  PEINADO CORTES, Liliana Mabel. Mathematical model of fibroblast migration process in ligament lesion. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.1, pp. 0-0. ISSN 1561-3011.

Fibroblast migration and proliferation is one of the different and more important stages in ligament repair process after a partial rupture of its fibers, II degree sprain. Experimental evidence demonstrates that in this stage a new extracellular matrix is produced and there, the fibroblasts answer in a favorable way to mechanical stimuli and increase the collagen synthesis, elastin, proteoglycans and growth factors improving the tissue biological and mechanical properties. The aim of present paper is to provide a mathematical model based on reaction-diffusion equations to describe the fibroblasts migration and proliferation process. The model proposed is solved by means of the finite elements method. The results obtained simulate the hemorrhage, the congestion and tissue edema at moment of lesion, growth factor release, and fibroblast migration and proliferation as well as the formation of new collagen fibers.

Keywords : Ligament; repair; mathematical model; reaction-diffusion equations; fibroblast migration; growth factors; II degree sprain.

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