Abstract

MARTINEZ BEDOYA, Darel. Visualization of liposomes by magnetic resonance imaging: an opportunity to improve antitumoral liposome therapies. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.4, pp. 417-428. ISSN 0864-0300.

Controlled release of drugs at the tumor site and the development of non-invasive monitoring techniques are two of the main challenges currently facing antitumoral therapies. The paper analyzes some of the potential uses of liposomes as vehicles for the transport of drugs to the tumors, particularly directionalized variants to tumor antigens through antibody coupling (immunoliposomes). These vesicles may also be used in combination with magnetic resonance, one of the most widely used imaging techniques, and one exhibiting great visualization potential at molecular level. Joint use of these two techniques makes it possible to control the amount of drug administered, as well as predict the efficacy of the treatment and monitor its progress.

Keywords : magnetic resonance; liposomes; cancer; immunoliposomes; gadolinium contrast agents.

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