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Revista Cubana de Investigaciones Biomédicas
On-line version ISSN 1561-3011
Abstract
FERIA DIAZ, Gisela Eduarda; GONZALEZ BENITEZ, Sonia Noemí and MIGUEL CRUZ, Manuel Alejandro. Genes involved in lung cancer. Rev Cubana Invest Bioméd [online]. 2021, vol.40, n.2 Epub June 01, 2021. ISSN 1561-3011.
Introduction:
Lung cancer is a serious global health problem due to its high prevalence and mortality. Lung carcinogenesis involves oncogenes and tumor suppressor genes which interact in complex manners with environmental factors, paving the way for the cancerous transformation.
Objective:
Describe the main genes involved in lung cancer.
Methods:
References were searched for in the databases PubMed Central, Annual Reviews and SciELO. Particular attention was paid to original papers, bibliographic reviews, systematic reviews and meta-analyses published in the last five years.
Data analysis and integration:
Lung carcinogenesis involves the oncogenes JUN, FOS, ABL1, BRAF, RAF1, GNAS, KRAS, NRAS, HRAS, CSF 1R, MYC, EGFR, MET, ALK, CCNE1, DDR2, ERBB3, FGFR1, MDM2, ROS1, SOX2 and TP63, and the tumor suppressor genes TP53, CDKN2A, CDKN1A, RB1, CDK2AP1, ATM, ERCC2, BRCA1, CCND1, STK11, PDLIM2, PTEN, ARID1A, ASCL4, CUL3, EP300, KEAP1, KMT2D, NF1, NOTCH1, RASA1, ETD2 and SMARCA4. Knowledge about the molecular genetics of lung cancer is important to identify more efficient diagnostic and prognostic biomarkers and to design targeted drugs for specific genes.
Keywords : lung cancer; carcinogenesis; targeted therapies; oncogenes; proto-oncogenes; tumor suppressor genes.