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Revista Cubana de Investigaciones Biomédicas
On-line version ISSN 1561-3011
Abstract
ALZATE MEJIA, Oscar Andrés et al. Physical and inflammatory condition before major abdominal quirurgical intervention. Rev Cubana Invest Bioméd [online]. 2023, vol.42 Epub Dec 01, 2023. ISSN 1561-3011.
Introduction:
Physical deconditioning is associated with, a decrease in cardiorespiratory capacity, an increase in body fat content and imbalances in the inflammatory response, all of which are risk factors for the aggression of a major surgical intervention. The oxygen consumption value (VO2max), body mass index (BMI), and plasma cytokine values of patients scheduled for major abdominal surgery are often not taken into account in the presurgical evaluation.
Objective:
To determine the physical and inflammatory condition of patients who were treated with a major abdominal surgery.
Methods:
Quantitative, descriptive research. Convenience sample of patients who underwent major abdominal surgery in two hospitals in Manizales (Colombia). Prior to the intervention, VO2max, BMI and cytokine values were measured.
Results:
6 men and 48 women participated in the study. Average VO2max values were categorized as low. High values of BMI, IL-1 receptor antagonist (IL-1 Ra) and brain derived neutrotrophic factor (BDNF) were found. No significant differences were found in the mean VO2max, IL-1Ra and BDNF values between the groups. Patients scheduled for gynecological and gastrointestinal surgery were overweight and those scheduled for bariatric surgery were morbidly obese.
Conclusion:
Patients scheduled for major abdominal surgery have low VO2max values for age and high BMI. High IL-1Ra and BDNF values were found associated with obesity and possible anti-inflammation.
Keywords : physical deconditioning; VO2max; obesity; IL-1 Ra; BDNF.