Abstract

CAMARAZA, María A et al. Response of antibodies induced by the Cuban meningococcal vaccine VA-MENGOC-BC® against the strain of Neisseria meningitidis B:4:P1.19,15, in teenagers after 12 years of being immunized. Vaccimonitor [online]. 2006, vol.15, n.3, pp. 1-4. ISSN 1025-0298.

The response of antibodies induced by the Cuban meningococcal vaccine VA-MENGOC-BC® against the strain of Neisseria meningitidis B:4:P1.19,15 was studied by the Serum Bactericidal Assay (SBA) and indirect ELISA, to measure antibodies against outer membrane vesicles (OMV) of N. meningitidis B in 184 teenagers of a polytechnical school of Ciego de Ávila who were immunized in massive campaigns 12 years before. Blood extractions were carried out before applying the first dose (T0), 4 weeks after the first dose (T1) and 4 weeks after the second dose (T2). After 12 years of this vaccination, 42% of teenagers presented bactericidal titers ≥ 1:4 against the homologous strain (B:4:P1.19,15) and 98% showed detectable antibodies against the OMVs. In the SBA, seroconversion percentage T1/T0 was 57% and T2/T0 was 60%. By ELISA, seroconversion was 59% and 54%, respectively. It was demonstrated that application of only one dose after 12 years induced an important immune response which can suggest an anamnesic response.

Keywords : Neisseria meningitidis; meningococcal disease; serum bactericidal assay; ELISA; immunological memory; vaccines.

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