Abstract

NARANJO, Mariela et al. vax-SPIRAL®, trivalent vaccine against canicola-icterohaemorragiae-pomona: Cross-protection capacity against challenge with highly pathogenic L. Ballum serogroup, in Syrian Golden Hamster Model. Vaccimonitor [online]. 2008, vol.17, n.2, pp. 14-19. ISSN 1025-0298.

The vaccine against Leptospirosis (vax-SPIRAL®) has been applied in risk groups against serogroups Canicola, Icterohaemorragiae and Pomona in Cuba since 1997. However, the epidemiological situation has changed and presently, the serogroup Ballum reaches the highest incidence. As a consequence, a study was conducted to know the grade of protection of vax-SPIRAL® against this serogroup. In this study the cross protection of vax-SPIRAL® against serogroup L. Ballum with one and two doses of the vaccine was evaluated in Syrian Golden Hamster model. In addition, different doses of the vaccine and different vaccinal lots were used. Prevalence of leptospira in target organ after the challenge with 100 and 10 000 DL50 of highly virulent L. Ballum strains (strains 12399, 42600 y 60) was determined in all cases. The results showed a complete cross-protection of immunized animal against lethal infection and the carrier state with one and two doses of the vaccine. Characteristic symptoms of the infection were not observed in the target organs.

Keywords : Leptospira Ballum; cross-protection; vax-SPIRAL®.

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