Abstract

PEREZ, Antonio; ZAMORA, Rosa  and  PAJON, Rolando. Meningococcal Disease. A case control study in the City of Havana , November 2003- July 2005. Vaccimonitor [online]. 2011, vol.20, n.1, pp. 1-7. ISSN 1025-0298.

Cuba has carried out a meningococcal immunization program since 1991. Current article aims at knowing the factors associated to meningococcal disease (MD) in vaccinated persons. The universe were the nine cases under 20 years old registered as MD from November 2003 to July 2005 in the City of Havana and 34 community controls to compare to the cases and to identify associated risk factors and to evaluate existing bactericide and ELISA antibodies against the outer membrane protein from serogroup B. Only seven cases were studied because one was out of the country and the other was a dead case. The 100% of studied cases showed the meningitis form, with an average hospital stay of 9.8 days and a lethality of 14.3% (1/7). Bivariate analysis showed no maternal nursing (OR 3.17 IC 95% = 0.44-27.85) associated to the occurrence of the disease. But it was not significant (p>0.05) due to the study universe. Multivariate analysis found out association with no maternal nursing (OR 3.22 IC95%= 0.52-19.52) but it also was not significant. Mann Whitney test to compare antibody titers against B antigen in both groups, showed a very significant difference (p<0.01) for the immune memory response to natural infection. The Cuban vaccine protects from MD caused by serogroup BC. The onset symptoms of the illness occurred with an average of four years after the second dose of the vaccine in 57 % of the cases.

Keywords : Meningococcal disease; associated factors; case-control; VA-MENGOC-BC(r).

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