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Revista Cubana de Medicina Militar
versión On-line ISSN 1561-3046
Resumen
HUU NGUYEN, Ben; VAN PHAN, Manh; DUY BUI, Hoan y MINH NGUYEN, Phuong. Effects of hyperbaric pressure on the oxidative stress status in healthy subjects. Rev. cuban. med. mil. [online]. 2023, vol.52, n.2 Epub 01-Jun-2023. ISSN 1561-3046.
Introduction:
In the hyperbaric pressure environment the partial pressure of each gas component increases, which increases oxygen partial pressure. This causes the generation of free radicals and oxidative stress.
Objective:
To determine the effects of hyperbaric pressure on the oxidative stress status in healthy subjects.
Methods:
29 healthy men performed standardized hyperbaric chamber dive to a depth of 30 meters of water (msw) for 30 minutes. Blood samples were collected before compression, immediately after decompression and 1 hour after decompression. The levels of Malondialdehyde, Catalase and Superoxide Dismutase were measured in blood samples.
Results:
Malondialdehyde activity increased immediately after decompression and recovered at 1 hour after decompression. Superoxide Dismutase enzyme activity decreased immediately after decompression as well as 1 hour after decompression. Catalase enzyme activity increased immediately after decompression, which was significant at 1 hour after decompression.
Conclusion:
Changes in the biological markers Malondialdehyde, Catalase and Superoxide Dismutase suggest the appearance of oxidative stress under the influence of a hyperbaric pressure environment.
Palabras clave : biological biomarker; catalase; decompression; free radicals; healthy volunteers; malondialdehyde; oxidative stress; superoxide dismutase.