Abstract

MORALES NAVARRO, Denia. General aspects of regenerative medicine in Dentistry. Rev Cubana Estomatol [online]. 2014, vol.51, n.2, pp.206-223. ISSN 0034-7507.

Introduction: the current revival and development of regenerative medicine and its wide range of therapeutic possibilities in dentistry is a topic of growing interest. Objective: carry out a bibliographic review about the general aspects of regenerative medicine in dentistry. Methods: a bibliographic review was performed which covered the period April-May 2013. An evaluation was conducted of high impact journals from the Web of Sciences (36 journals) and 3 Cuban journals. Databases from reference systems such as MEDLINE, PubMed and Scielo were consulted with the aid of search terms like "regenerative medicine dentistry", "stem cells", "tissue engineering" and their Spanish counterparts. The review included papers in English and Spanish, and publications from the last five years. Only one paper had been published before that period. Of the 120 papers obtained, the reviewers selected the 56 which approached the study topic in a more comprehensive manner. One book was reviewed. Results: an analysis of the representativeness of papers in the scientific journals where they were published showed that 7,02 % corresponded to the Cuban Journal of Hematology, Immunology and Hemotherapy, a sign of the importance awarded to the subject in the country. The remaining papers were scattered among the other journals. Conclusions: knowledge about the theoretical foundations of regenerative medicine as applied to the substitution of healthy cells for cells damaged by various processes in certain tissues, justifies its potential use in dentistry, based on the correct application of the concepts of regenerative medicine, stem cells (including its action mechanisms, types, sources), soluble factors, gene transplantation and tissue engineering.

Keywords : regenerative medicine; dentistry; stem cells; tissue engineering; soluble factors; gene transplantation.

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