My SciELO
Services on Demand
Article
Indicators
- Cited by SciELO
Related links
- Similars in SciELO
Share
Revista Cubana de Estomatología
On-line version ISSN 1561-297X
Abstract
DE SOUZA BORGES, Maria Heloísa et al. Cinnamaldehyde and terpineol as inhibitors of Candida albicans and Enterococcus faecalis biofilms. Rev Cubana Estomatol [online]. 2021, vol.58, n.2 Epub Jan 29, 2021. ISSN 1561-297X.
Introduction:
Phytoconstituents are natural molecules displaying satisfactory antimicrobial activity. Studies should be conducted about their use as new root canal irrigants.
Objective:
Evaluate the inhibitory effect of the phytoconstituents cinnamaldehyde and α-terpineol against mono- and duo-species biofilms of microorganisms involved in endodontic infection.
Methods:
An experimental applied microbiology blind randomized in vitro study was conducted. The phytoconstituents selected were cinnamaldehyde and α-terpineol. Antimicrobial activity against Candida albicans and Enterococcus faecalis was evaluated by metabolic capacity analysis with resazurin and cell viability analysis by the plaque. The culture medium and 1% chlorhexidine served as negative and positive controls, respectively.
Results:
An absence of growth was observed for exposure of the biofilms at concentrations of 10 and 5 mg/ml of both phytoconstituents. At a concentration of 2.5 mg/ml terpineol displayed growth only in the mono-species biofilms of C. albicans and duo-species biofilms. At a concentration of 1 mg/ml terpineol and cinnamaldehyde displayed growth in all biofilms.
Conclusions:
Cinnamaldehyde and α-terpineol displayed inhibitory activity against mono- and duo-species biofilms of Candida albicans and Enterococcus faecalis at concentrations of 10 and 5 mg/ml.
Keywords : biological products; cell survival; anti-infectives.