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Revista Cubana de Estomatología

On-line version ISSN 1561-297X


ADAN SOCARRAS, Leodanyi et al. Post-surgical pain and edema in nasal skin regeneration with fibrin rich in platelets and leukocytes. Rev Cubana Estomatol [online]. 2023, vol.60, n.2  Epub June 01, 2023. ISSN 1561-297X.


The reconstruction of nasal skin defects requires the use of procedures aimed at obtaining the lowest probability of postoperative complications in the shortest period of time possible. Novel techniques use platelet concentrates for their modulating properties of pain and postoperative edema.


To determine the behavior of pain and post-surgical edema in the regeneration of nasal skin defects with the use of autologous platelet- and leukocyte-rich fibrin membrane.


A quasi-experimental research was carried out, with a before-after design, without a control group, in the Maxillofacial Surgery Service at Arnaldo Milián Castro University Hospital in Santa Clara, Villa Clara, Cuba, from September 2015 to June 2015. 2019. The randomly selected sample was 46 patients. A fibrin membrane rich in platelets and leukocytes was obtained from a patient's blood self-donation, which was sutured in the nasal surgical defect.


The mean age was 62.71 years and 60.87% of the sample was male. Pain was present in 23.91% and edema in 28.26% of the studied sample.


Few postoperative complications such as pain and edema were found, showing to be mild predominantly. There was association between these complications and age, the number of affected anatomical subunits, diabetes mellitus and smoking habit.

Keywords : nasal surgical procedures; platelet- and leukocyte-rich fibrin; regenerative medicine; targeted tissue regeneration.

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