Abstract

SERRATE, María Antonia; LORENZO, María de los Ángeles  and  ARANGO, Ramón. Desarrollo tecnológico de la formulación de cápsulas de ampicilina 250 y 500 mg. Rev Cubana Farm [online]. 1997, vol.31, n.2, pp. 86-90. ISSN 1561-2988.

The technological development to produce the formulation of capsules of ampicillin trihydrate using again the products obtained through the dry procedure representing the 30 % of it, is described. A wet procedure was used because of the characteristics of the powder obtained and a current product was obtained having the proper characteristics for its use. Capsules of 250 and 500 mg were subjected to stability studies at controlled temperature and the physical and chemical characteristics that may comply with the granulate were also determined. This reutilization of fine products through the dry procedure makes it possible to attain an optimun use of the raw material employed for this production.

Keywords : TECHNOLOGICAL DEVELOPMENT; CHEMISTRY PHARMACEUTICAL; AMPICILLIN; CAPSULES; DRUG STABILITY.