Abstract

VILLALON REVILLA, Carlos; VISTEL VIGO, Marlen  and  BOSCH ESCOBAR, Jorge. Determinación de la disolución en tabletas de trifluoperazina 1 mg por el método de colorantes ácidos. Rev Cubana Farm [online]. 1998, vol.32, n.1, pp. 28-33. ISSN 1561-2988.

As spectrophotometric procedure was developed by using a methods of acid coloring matters with tropeolin 00 for the determination of the solution in trifluoperazine 1 mg tablets under the conditions of dissolution of the USP 23. The value of the ph selected for the maximun partition of the coloring matter-trifluoperazine complex in chloroform was of 2.5, in which the complex had a maximum absorbency at 408 nm. The lineality, accuracy, exactitude and robustness of the method were evaluated in model solutions of trifluoperazine of exactly known concentrations that allowed to demonstrate the reliability of the analytical process developed, and to determine its adoption as an alternative method to control the quality of the product.

Keywords : SPECTROPHOTOMETRY [methods]; TRIFLUOPERAZINE; TABLETS; DRUG QUALITY; CHEMISTRY, PHARMACEUTICAL.