Abstract

TOLOSA CUBELA, Vivian et al. Estabilidad de las tabletas de clorodiazepóxido 10 mg. Rev Cubana Farm [online]. 1998, vol.32, n.1, pp. 45-51. ISSN 1561-2988.

The stability of chlordiazepoxide 10 mg tablets, which were made with low cost modified starch (GECLYN-ER2) to substitute gelatine, the traditional agglutinant, was studied. The following analytical methods were used for the quantification and identification of chlordiazipoxide: high pressure liquid chromatography thin layer chromatography, and spectrophotometry. The results attained for the tablets exposed to different conditions of temperature, humidity and shelf life confirmed the feasibility of this starch that was modified to make chlordiazepoxide 10 mg tablets.

Keywords : BENZODIAZEPINE TRANQUILIZERS; CHROMATOGRA-PHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; SECTROPHOTOMETRY; DRUG STABILITY.