Abstract

FERNANDEZ SERRET, Alfredo; ARTAU FLAIFEL, Caridad  and  ALONSO JIMENEZ, Esther. Estabilidad de las tabletas de ribofen 80 mg. Rev Cubana Farm [online]. 1998, vol.32, n.1, pp.45-51. ISSN 0034-7515.

The stability study of the ribofen 80 mg tablets was developed and their expiration date was determined. This study was conducted by the shelf life and accelerated stability with the utilization of high pressure liquid chromatography. The humidity effect on the stability of the product was also analyzed by placing samples into hydrostats with controlled humidities. This drug met the parameters of quality established for this product. The results of the stability study by shelf life and of the dissolution assay after 6, 12 and 24 months showed that the product maintain the parameters determining its quality. Besides, no changes were observed in its organoleptic aspect.

Keywords : DRUG STABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID [methods]; ANTIINFLAMMATORY AGENTS.