Abstract

RUIZ CABALLERO, Ritsie; AVILA GONZALEZ, Rizette  and  GONZALEZ LAVAUT, José A. Propranolol y sus ésteres: detección y resolución enantiomérica. Rev Cubana Farm [online]. 1998, vol.32, n.2, pp.130-139. ISSN 0034-7515.

A bibliographic review on the raceme of propanolol chlorhydrate and its esters was made aimed at compiling the latest methods for its detection and the resolution of its racemic mix in order to provide information to pharmacists, synthesizer chemistry and other professionals connected with this topic. Reference was made to the MEDLINE (1986-1994), Analytical Abstracts (1985-1994), and Chemical Abstracts (1990-1992) data bases, as well as to Current Contents (Life Science & Physical, Chemical & Earth Sciences) form 1990 to 1996. The spectrofluorometry, the colorimetry, the thinlayer chromatography, and the high oressure liquid chromatography are reported as analysis techniques used for its detection. The following methods of resolution of enantiomers are considered: supercritical fluid chromatography, capillary electrophoresis, thin-layer chromatography and high pressure liquid chromatography using phases and/or chiral additives. The last two are used for the detection and resolution of propanolol hydrochloride and its esters.

Keywords : PROPANOLOL [analogs & derivatives]; CHROMATOGRAPHY, THIN LAYER [methods]; SPECTROMETRY, FLUORESCENCE [methods]; COLORIMETRY [methods]; CHROMATO-GRAPHY, HIGH PRESSURE LIQUID [methods].

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )