Abstract

PERDOMO LOPEZ, Iliana et al. Ungüento ZZ, antiséptico elaborado con una zeolita natural modificada. Rev Cubana Farm [online]. 1998, vol.32, n.3, pp. 169-173. ISSN 1561-2988.

ZZ oinment was designed from an active zeolite product which has a marked antimicrobial effect in the treatment of micosis and bacterial affections. Three different formulations were evaluated for the product through physicial-chemical determinations. Formulation I used hidrophil oinment as a base; formulation II used drying cream and Formulation III chose an oil-in-water emulsified base. As a result of this assessment, formulations I and II were not chosen because of the interaction of the active agent with sodium laurylsulphate and with glyceril monostereate respectively. Formulation III turned out to be the most suitable from the technological viewpoint. Toxicological studies were performed on this formulation to observe skin irritability but the results were favourable since there was no trace of irritation in the treated areas.

Keywords : OINMENTS; ZEOLITES; ANTI-INFECTIVE AGENTS; LOCAL; CHEMISTRY, PHARMACEUTICAL; DRUG EVALUATION; DRUG STABILITY..

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