Abstract

LEON RODRIGUEZ, Rafael; GONZALEZ CALZADILLA, Alexander; MARTINEZ ALVAREZ, Luis  and  ROBERTO CORDOVES, Yamilka. Estudio de preformulación del citrato de dietilcarbamazina. Rev Cubana Farm [online]. 1999, vol.33, n.2, pp. 104-110. ISSN 1561-2988.

The study of diethycarbamazine citrate preformulation with a view to finding uot the physico - chemical and tachnological characteristics of this pharmaceutical for further production of a 50 mg tablet was performed. This study included the determination of the size of micronized and non-micronized particles by optical microscopy in which the influence of size on the pharmaceutical dissolving in vitro was shown. Drug - excipient incompatibility was analysed using differential scannig calorimetry and no interaction was found under experimental working conditions. Other physico-chemical & technological properties of this pharmaceutical were examined.

Keywords : DIETHYCARBAMAZINE [chemistry]; FILARCIDES [chemistry]; CHEMISTRY, PHARMACEUTICAL.

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