Abstract

RUIBAL BRUNET, Ignacio Juan et al. Inhibición de la replicación del virus de inmunodeficiencia humana por extractos de taninos de Pinus caribaea Morelet. Rev Cubana Farm [online]. 2003, vol.37, n.2, pp. 0-0. ISSN 1561-2988.

Six different fractions from the bark of Pinus caribae Moralet var. caribae were faced in five different concentrations against two viral doses (MOI 0,1 y 0,01) in a vitro assay on MT4 cell lines; the antiviral activity was measured by p24 Ag capture ELISA assay (DAVIH Agp24). All the fractions showed a mild cytotoxicity activity and only one fraction showed the highest cytotoxicity activity. The fraction 02 had the highest percentage of viral replication inhibition, correlated with the viral dose and the product concentration, having a selectivity rate of 100; however, more research about the chemical structure of active compounds, and possible mechanisms of action are needed.

Keywords : TANNINS [therapeutic use]; HIV-1; ANTIVIRM AGENTS [toxity].