SciELO - Scientific Electronic Library Online

 
vol.37 issue3Indicaciones del meprobamato en personas de 60 años de edad y más en Ciudad de La Habana, 2000-2001Morinda citrifolia Linn: potencialidades para su utilización en la salud humana author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista Cubana de Farmacia

On-line version ISSN 1561-2988

Abstract

JIMENEZ LOPEZ, Giset et al. Comportamiento de las reacciones adversas a los analgésicos y antiinflamatorios no esteroideos notificadas por el Sistema Cubano de Farmacovigilancia en el 2001. Rev Cubana Farm [online]. 2003, vol.37, n.3, pp. 1-1. ISSN 1561-2988.

The analgesics and nonsteroideal antiinflammatory drugs share some therapeutic activities and side effects. Their action mechanism is mediated by the inhibition of cyclooxygenase (COX 1 and 2), an enzime incharge of the biosynthesis of prostaglandins and other similar autacoids. A periodical analysis of the notified suspicions of adverse reactions was made at the Coordinating Unit of Pharmacosurveillance. In 2001, it was observed that of the 10 drugs suspected of producing a higher number of adverse reactions, 50 % corresponded to the group of analgesics and nonsteroideal antiinflammatory drugs that is at the same time one of the groups with the highest consumption in the country. A description of the behavior of the suspicions of adverse reactions related to aspirin, dipyrone, indomethacin, ibuprofen, naproxen, paracetamol and pyroxicam, including severity, demographic characteristics, and their physiopathological mechanism, was made. 16 195 notifications containing a total of 33 601 adverse reactions, of which 21.5 % corresponded to analgesics and nonsteroideal antiinflammatory drugs, the most notified group after the antimicrobial agents, were received at the Coordinating Unit of Pharmacosurveillance, in 2001. It was observed that the most severe affections affected the hematological and gastroinestinal systems and the body as a whole. Females and the young adults were the most affected. Due to the reported reactions and to the severity of them, it is necesary to maintain an active surveillance on this pharmacological group and to make an adequate prescription in order to reduce the risk for suffering from adverse reactions.

Keywords : ANALGESICS [adverse effects]; ANTIINFLAMATORY AGENTS, NON-STEROIDAL [adverse effects].

        · abstract in Spanish     · text in Spanish

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License