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Revista Cubana de Farmacia

Print version ISSN 0034-7515On-line version ISSN 1561-2988


DE LA PAZ NARANJO, José; CORRAL SALVADO, Aida; MARTINEZ RUIZ, Carlos  and  MARTINEZ MARTIN, Sara. Antidiarrheal effect of Mentha piperita Linn tincture 20 % in rats. Rev Cubana Farm [online]. 2004, vol.38, n.2, pp.1-1. ISSN 0034-7515.

To evaluate the antidiarrheal action a Mentha piperita Linn (toronjil de menta ) tincture 20 %, an in vivo study was carried out in a model of diarrheas in rats induced by beaver oil. The evaluated doses were 200, 300 and 400 mg/kg. It was found that the doses of 300 and 400 mg/kg prolonged the time of appearance of the first liquid defecation and reduced its frequency. It was not so with the smaller dose, which only reduced the number of liquid defecations in time. It was also found an effect depending on the dose and an effective mean calculated dose (ED50) of 346.41 mg/kg. The maximum dose of tincture proved to have an antidiarrheal action in the model used. The level of significance was fixed in a p £ 0.05.

Keywords : Mentha piperita Linn; diarrheas; antispasmodic; rats; beaver oil; animal model.

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