Abstract

ALONSO MORENO, Yamisleydi; TRAPERO QUINTANA, Yoagne María  and  TRAPERO QUINTANA, Yoagne María. Acute oral toxicity of o-vanillin. Rev Cubana Farm [online]. 2008, vol.42, n.1. ISSN 0034-7515.

2-hydroxy-3-methoxybenzaldehyde (o-vanillin) has a proven anitsickling activity and a low haemolytic activity on SS and normal red corpuscles, so it may be efficient in the treatment of drepanocytic anemia, a genetic disease of high prevalence at the world level. In this sense, an acute oral toxicity study was conducted aimed at determining its adverse effects. A dose of 2 000 mg/kg of body weight was administered to a group of rats (3 females and 3 males), where the vehicle was given to the control group. The animals were observed for 14 days. The variations of weight, the presence or not of symptoms and clinical signs, and the necropsy at the end of the study were determined. Body weight reduction was not observed in any of the experimental groups. They presented symptoms such as piloerection, accelerated breathing, reduced activity, grooming, and isolation on the corner of the cage. One animal died. The macroscopic analysis of the organs did not detect any variation. The DL 50 of o-vanillin was over 2000 mg/kg of body weight according to the globally harmonized system

Keywords : Acute oral toxicity; 2-hydroxy-3-methoxybenzaldehyde; o-vanillin; antisickling activity; drepanocytic anemia.