Abstract

ARCE FERNANDEZ, Eva  and  VILLAFUERTE ROBLES, Leopoldo. Technological characteristics of mixtures of sennosides A + B with excipients for tablet formulations. Rev Cubana Farm [online]. 2008, vol.42, n.3, pp. 0-0. ISSN 1561-2988.

The technological properties of concentrates of sennosides A+B were studied with the purpose to evaluate the feasibility of its processing to the pharmaceutical form of tablets. The studied properties include the compactibility, the ejection pressure, the disintegration time and the rate of the powder flow. The obtained results show that a mixture of microcrystalline cellulose with colloidal silica is a suitable excipient to increase to the double the powder flow rate and 4 times the tablet strength and to reduce in 40 % the time necessary to disintegrate the tablets. The above mentioned formulation modifications do not affect in an important manner the gliding properties of the tablets being ejected from the die where they were compressed.

Keywords : Sennosides A+B; pharmaceutical technology; powder flow; compactibility; disintegration time.