Abstract

GALAN MARTINEZ, Loipa. Statines, a new therapeutical option for many diseases. Rev Cubana Farm [online]. 2009, vol.43, n.4, pp.102-113. ISSN 0034-7515.

Statins inhibiting the enzyme 3-hydroxy-3-methylglutaril- coenzyme A reductase decrease the cholesterol production and besides, to prevent the non-steroidal isoprenoids compounds acting like lipid couplings for post-translation modification of some proteins involved in different cellular processes. The isoprenilation process blockade given by statins treatment hass too biological effects on cellular functions beyond the decrease in cholesterol synthesis: these are the so called pleiotropic effects mainly related to vascular function, including an improvement of hypertrophy and its congestive cardiac insufficiency and vascular hypertrophy and have anti-inflammatory properties, inhibiting the cancerous cells proliferation, immunomodulation, improving the endothelial dysfunction and reducing the ischemia-reperfusion damages. This review describes the pleiotropic effects of statins as well as the molecular mechanisms used to exert different biological functions.

Keywords : Statins; cardiovascular diseases; endothelial dysfunction; hypocholesterolemia.

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