Abstract

GARCIA PENA, Caridad Margarita et al. Assessment of the oral acute toxicity and the antimicrobial activity of an oily mixture from shark's liver of Cuba. Rev Cubana Farm [online]. 2010, vol.44, n.3, pp.374-380. ISSN 0034-7515.

The total acute toxicity and the antimicrobial activity of an oil mixtures from shark liver of Rhicodon typu (whale-shark) and Galeocerdo cuvier (tigger-shark) was assessed in species leaving in the adjacent costs of Cuban northern coastal for its subsequent pharmaceutical use due to its high content of vitamins and fatty acids and its antioxidant and anti-inflammatory activity. Study of oral acute toxicity demonstrated that oil mixture of shark liver hasn't macroscopic alterations in removed organs, severe toxic symptoms and on mortality of any animals used in study at 20 mL/kg dose. Study results of antimicrobial activity showed a slight bacteriostatic activity against K. pneumoniae and an antifungal activity against Microsporum canis, and a resistance against C. albicans and T. mentagrophytes at assessed concentrations.

Keywords : Oral acute toxicity; shark liver oil; Rhincodon typu; Galeocerdo cuvie.

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