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Revista Cubana de Farmacia

Print version ISSN 0034-7515


RODRIGUEZ AMADO, Jesús Rafael; LAFOURCADE PRADA, Ariadna; ESCALONA ARRANZ, Julio César  and  IRAIZOZ COLARTE, Antonio. Preformulation of tablets from Tamarindus indica L.. Rev Cubana Farm [online]. 2011, vol.45, n.4, pp.553-562. ISSN 0034-7515.

A pre-formulation study for tablet preparation using soft extract from Tamarindus indica L. leaves was conducted. Possible interactions in binary mixtures of Tamarindus indica L. soft extract and selected excipients in a 1:3 ratio, which may affect the amount of polyphenols in the mixture at 30°, 45° and 60 °C temperatures, were analyzed. Three preliminary tablet formulations were designed and then the quality of granules and tables were researched in all the cases. It was concluded that there were no interactions affecting the color, the smell and the polyphenol concentration in the evaluated binary mixtures at 30°. At higher temperatures, the amount of polyphenols decreased. Pre-formulation number 3 yielded the best technological quality in tablet production and thus can be used for future formulation and optimization studies of Tamarind tables.

Keywords : preformulation; Tamarind; binary mixtures; tablets; polyphenols.

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