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Revista Cubana de Farmacia

Print version ISSN 0034-7515


BENAVIDES AREVALO, Julie Fernanda  and  TOBON ZAPATA, Gloria Elena. Evaluation of the reactive fractal dimension of magnesium, manganese and zinc glycinates. Rev Cubana Farm [online]. 2012, vol.46, n.1, pp.11-20. ISSN 0034-7515.

Introduction: Complexes of glycine and cations magnesium, manganese and zinc, could be included in the formulation of a nutritional supplement that provides adequate absorption of these metals into the body without gastrointestinal disturbances. Objective: to study the solubility of complexes of glycine and cations manganese, zinc and magnesium. Methods: dissolution and image analysis studies were performed. The synthesis and verification of the formation of complexes were carried out by infrared spectroscopy, differential scanning calorimetry, thermal gravimetric analysis, and X-ray diffraction of dust. Results: the image analysis showed some descriptors such as circularity, the Ferret diameter and the fractal dimension. The latter was related to the water dissolution process in order to obtain two associated properties, that is, the surface fractal dimension and the reactive fractal dimension, Conclusions: these results showed that the dissolution of glycinates occurs through the pores or cracks found in their particle surfaces and that these complexes are suitable for use in nutritional formulations as sources of magnesium, manganese and zinc.

Keywords : glycine; glycinate; fractal dimension; dissolution studies.

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