Abstract

DELGADO ROCHE, Livan; VAZQUEZ LOPEZ, Ana María  and  MARTINEZ-SANCHEZ, Gregorio. Pathogenic molecular processes of atherosclerosis and therapeutic alternatives for control. Rev Cubana Farm [online]. 2012, vol.46, n.2, pp. 267-280. ISSN 0034-7515.

Atherosclerosis is a chronic vascular disease which affects bifurcations of major arteries. Atherosclerosis-associated cardiovascular diseases represent the first cause of mortality in the western world. The physiopathology of atherosclerosis associates a variety of molecular and cellular complex events, which are not completely understood. However, some hypothesis have been postulated to explain the pathogenic events during atherogenesis. The objective of the present article is to offer an updating on the principal molecular events during the atherosclerosis development and therapeutic alternatives for its treatment and control. To this end, a literature review was made in MEDLINE database, which covered the scientific publications of the last 10 years. The complexity of this illness was analyzed in depth and it was demonstrated that there was not any completely effective therapy to treat it.

Keywords : atherosclerosis; oxidative stress; low density lipoproteins; inflammation; autoimmune disease; antioxidants.

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