Abstract

POMIER SUAREZ, Olga et al. Oxidative stress indicators for HIV/AIDS patients with rheumatologic manifestations. Rev Cubana Farm [online]. 2012, vol.46, n.3, pp.329-342. ISSN 0034-7515.

Introduction: the oxidative stress has been recognized as a cofactor in the progression of the human immunodeficiency virus (HIV) infection and in the rheumatologic manifestations. Objective: to assess the oxidative stress indicators in those HIV patients with rheumatologic manifestations. Methods: thirty one HIV patients with rheumatologic manifestations were studied and the evaluated indexes were compared to those of a control group made up of 31 apparently healthy individuals. The patients were classified according to the following activity criteria: scale of the disease activity for the rheumatologic manifestations, and index of disease activity and the analogical visual scale of pain at night in terms of the rheumatologic manifestations. The plasma concentrations of the oxidative stress indexes were measured by spectrophotometric techniques. Statistical analysis was made using SPSS 13 program. Results: the evaluated HIV patients presented with moderate to severe oxidative stress, characterized by significant increase in the oxidative damage parameters and decrease in the antioxidizing systems (p< 0.05) after a comparison with those parameters of an apparently healthy control group in terms of age and gender. No statistically significance was found in the studies carried out to relate rheumatologic manifestations, time elapsed from the HIV confirmation, gender, CD4 lymphocyte T count and the viral load. Conclusions: the collected data showed that the oxidative stress indicators could be useful in treating and following-up the HIV patients with rheumatologic manifestations.

Keywords : oxidative stress; HIV; reactive oxygen species; rheumatologic manifestation.

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