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Revista Cubana de Farmacia

Print version ISSN 0034-7515


JIMENEZ MARTINEZ, María del Carmen; PADILLA DOCAL, Bárbara  and  CISNEROS HECHAVARRIA, Virgen María. Antimicrobial therapy of meningoencephalitis at "Luis Diaz Soto" central military hospital, 2004-2011. Rev Cubana Farm [online]. 2014, vol.48, n.1, pp.34-42. ISSN 0034-7515.

Introduction: meningoencephalitis represents a group of diseases of high impact among the infective diseases whose cure was possible thanks to the introduction of antibiotics, but morbidity and mortality rates remain high. Objective: to identify the antimicrobial therapy used in meningoencephalitis. Methods: retrospective, descriptive and observational study. One hundred and fifty patients were studied, who had been diagnosed with viral or bacterial meningoencephalitis through confirmed clinical picture, cytochemical study of the cerebrospinal fluid or identified etiological agent. All of them were seen from 2004 through first semester of 2011 at the medical and pediatric services of "Dr Luis Diaz Soto" central military hospital. The study design was drug use including indication-prescription and the therapeutic scheme for this type of patient. Results: antimicrobial therapy was used in 18.67 % of cases with viral meningoencephalitis (23.93 % out of 117 patients) and 22 % with bacterial type (100 %, 33 cases). The most common antibiotic therapies were ceftriaxone (as single antibiotic) in viral meningoencephalitis, and ceftriaxone plus vancomycin (combined) in bacterial meningoencephalitis. The most isolated pathogen was Streptococcus pneumoniae treated in most of cases with the referred combination of drugs. In general, treatment for bacterial meningoencephalitis lasted less than 21 days. Conclusions: the study showed the use of antimicrobial therapies to treat patients with viral meningoencephalitis and the agreement between the empirical and the specific therapy to manage bacterial meningoencephalitis.

Keywords : meningoencephalitis; Streptococcus pneumoniae; Haemophilus influenzae; Neisseria; antibiotic; drug use study.

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