Abstract

CONTRERAS PUENTES, Escarleth; DIAZ CABALLERO, Antonio  and  TARON DUNOYER, Arnulfo. Cyclotides, circular proteins produced by plants with pharmacological potential. Rev Cubana Farm [online]. 2015, vol.49, n.2, pp. 384-393. ISSN 1561-2988.

The ciclotydes are circular proteins of 28 to 37 aminoacid that have a unique and strong cyclic structural motif which confers stability and relevant biological activities. In this study we searched in data bases EBSCOHOST, Science Direct, Pubmed and ACS publication to identify relevant studies considering inclusion criteria such as full-text articles in English, original experimental research related to the use of cyclotides in drug design. The biological activities of the cyclotides have been reported as insecticide, uterotonic, antimicrobial, antiHIV, anticancer, hemolytic, neurotensin antagonist and inhibitor of trypsin which can be used as basis for the development of new drugs that can be applied to the treatment of various diseases.

Keywords : ciclotydes; circular peptides; drugs; structure; biological activity.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )