Abstract

ZAYAS DIAZ, Mercedes; MENENDEZ ALEJO, Francisco  and  MENENDEZ ALEJO, Ibis. Paraplejía espástica familiar y artritis reumatoidea. Rev cubana med [online]. 1997, vol.36, n.3, pp.198-201. ISSN 0034-7523.

Clinical and laboratory findings of a patient presenting with familial spastic paraplegia in its pure form and associated with rheumatoid arthritis, are reported. The first symptoms of familial spastic paraplegia occurred during adolescence suggesting a form of autosomal dominant hereditary disease. Rheumatoid arthritis was characterized by polyarticular lesions, positive rheumatoid factor, high sedimentation rate, and the phenotype SZ of alpha-1-antitrypsin. It is concluded that the association between both entities may be due to a primary genetic defect located in the large arm of chromosome 14.

Keywords : SPASTIC PARAPLEGIA, HEREDITARY [complications]; ARTHRITIS, RHEUMATOID [complications]; ALPHA-ANTITRYPSIN [deficiency]; PHENOTYPE, SPASTIC PARAPLEGIA, HEREDITARY [genetics].