Abstract

PICO BERGANTINOS, María Victoria; RUIZ GONZALEZ, Marlen; PICO BERGANTINOS, Thais  and  GARCIA PEREZ, Miguel. Marcadores biológicos para el diagnóstico y tratamiento del asma bronquial. Rev cubana med [online]. 1999, vol.38, n.1, pp.24-34. ISSN 0034-7523.

Intrinsic and allergic bronchial asthma has been defined as a persistent chronic inflammatory disorder based on increasing evidences. It has been proved that the clinical characteristics of bronchial asthma are connected with cellular parameters a well as with substances produced by bronchial inflammation processes. Therefors, took for evaluation and monitoring of asthmatic inflammation are being studied according to these variables that may allow to know the diagnosis and evolution of asthma at the same time. As eosinophils, T-limphocytes, mastocytes, macrophages, neutrophils, epithelial and structural cells, some proinflammatory mediators and proteins, particularly those from the eosinophil granules, have been involved in the pathogenesis of bronchial asthma, it has been anticipated that some of them may be used in the diagnosis of bronchial asthma or may serve as markers for monitoring subjacent bronchial inflammation. It was made a review of the present state of opinion regarding these mediators, which were included in this paper.

Keywords : ASTHMA [diagnosis]; BIOLOGICAL MARKERS [analysis]; ASTHMA [immunology]; EOSINOPHILS [immunology]; T-LYMPHOCYTES [immunology].

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