Revista Cubana de Medicina
On-line version ISSN 1561-302X
GUEVARA GARCIA, Mariela et al. Cellular and molecular mechanisms of ischemic cerebrovascular disease. Rev cubana med [online]. 2004, vol.43, n.4, pp. 0-0. ISSN 1561-302X.
A bibliographic review was made on the cellular and molecular mechanisms that are produced in the ischemic cerebrovascular disease. The failure in the energy production, lactic acidosis, increase of cytosolic calcium, excess of free radicals and extracellular crowd of neurotransmissors, with the subsequent activation of receptors and neuronal stimulation under circumstances of poor glucose and oxygen supply seem to be important steps in the processes leading to neuronal death.These mechanisms would lead to a secondary damage of cerebral microcirculation due to edema and endothelial lesion, formation of intravascular cellular aggregates and alterations of permeability and vascular reactivity that would cause the "non reflux" phenomenon, the circle would close and the process would be perpetuated. This series of chemical reactions in the nervous cells and the knowledge of these alterations of cellular metabolism are very interesting, since they allow to investigate drugs that by blocking this chain of reactions lead to a better functional recovery.
Keywords : Ischemic cebrovascular disease; cellular mechanisms; molecular mechanisms; free radicals; neurotransmissors; ischemic cascade.