Abstract

BORROTO DIAZ, Gerardo et al. Frequency of insulin resistance and/or insulin secretory deficit and its connection with risk factors for hyperglycaemia in patients with kidney transplants. Rev cubana med [online]. 2008, vol.47, n.1, pp. 0-0. ISSN 1561-302X.

Insulin resistance and the deficit in the pancreatic secretion of this hormone are the pathogenic factors of hyperglycaemia associated with kidney transplant, a frequent and multifactorial process that complicates the evolution of these patients. A PTGO of 2 h with dosage of insulin was performed among 83 patients who had undergone renal transplants during their follow-up at the outpatient department. Insulin resistance (48 %) and the decrease of hormonal secretion (23.1 %) were determined by using the indexes HOMA S and B % in order to know the frequency of these disorders, the role of the deficiency in the secretion and/or action of insulin and its association with risk factors, excluding the immunosuppressive treatment. A high frequency of disorders in the glucose metabolism (50 %) and an evident association with factors considered as risk for posttransplant hyperglycaemia were confirmed. It was found that the oldest age, the longest time under dialysis, as well as an elevated body mass index, plus weight gain at the third month of the transplant, the family history of diabetes, the hepatitis C virus infection and the high figures of pretransplant triglycerides, were statistically significant in patients with pathological insulin indexes.

Keywords : Hyperglycaemia associated with transplant; insulin resistance; insulin deficit; HOMA indexes; kidney transplant; risk factors.

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