Abstract

SANTANA TELLEZ, Tomás Noel; MONTEAGUDO CANTO, Alina; DEL AGUILA GRANDEZ, Angie Y  and  VAZQUEZ GAMBOA, Antonio. Effectiveness of captopril microdosing in the treatment of essential arterial hypertension. Rev cubana med [online]. 2012, vol.51, n.3, pp. 247-257. ISSN 0034-7523.

Introduction: prescribing the appropriate therapeutic treatment is always a complex task, particularly when drug control and safety indices do not accomplish the expected goals. In such a context, microdosing could be an effective alternative. Objective: evaluate the effectiveness of captopril microdosing in the treatment of essential arterial hypertension. Methods: aunicenter controlled randomized phase III clinical trial was conducted at Manuel Ascunce Domenech University Hospital in the province of Camagüey from January 2007 to December 2009. A form was prepared which included the following variables: clinical control, age group, hypertension grade, cardiovascular risk grade, minimum dose required for control. The information collected was subjected to statistical processing and analysis with the software SPSS versión 15.0. Statistical techniques were used to find differences between the variables. Results: captopril microdosing was more effective than tablets for the long-term treatment of arterial hypertension, particularly in patients aged 60 and over, grade II and III hypertensives, and higher risk patients, even with the use of a smaller dose. Conclusions: captopril microdosing was found to be effective for the treatment of essential arterial hypertension, allowing a better clinical control with a smaller dose of the medication.

Keywords : microdosing; captopril; arterial hypertension.

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