Abstract

SOLER MOREJON, Caridad de Dios; LEON PEREZ, David; LARRONDO MUGUERCIA, Hilev  and  AGUSTIN GODOY, Daniel. Biochemical and molecular response to acute brain damage. Rev cubana med [online]. 2014, vol.53, n.1, pp. 76-90. ISSN 0034-7523.

Acute brain injury triggers, among others responses, a group of biochemical and molecular disturbances that so far, are not enough characterized. These disturbances enhance the previous brain damage or generate additional ischemic insults amplifying this response. Dysglycemia, sodium and osmolarity disturbances, and local and systemic inflammatory response are among the most relevant. As their clinical pictures are different, and occasionally unnoticed, these disorders can represent a real challenge for the intensivist. Biochemical and molecular disturbances after an acute brain damage are not the priority in the management of these patients, however it is important their early recognition, monitoring and adequate treatment to avoid the secondary brain damage. Together with hypoxemia and hypotension they can contribute significantly to worsen the prognosis and mortality because they can define the magnitude of the final neurologic deficit.

Keywords : acute brain damage; biochemical disturbances; molecular disturbances; brain damage; dysglycemia; sodium disturbances; osmolarity; inflammatory response.

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