Abstract

GONZALEZ GONZALEZ, Elizabeth; BACALLAO MENDEZ, Raymed Antonio; GUTIERREZ GARCIA, Francisco  and  MANALICH COMAS, Reinaldo. Stimation of renal function from serum creatinine and predictive formulas in Cuban population with lithiasic. Rev cubana med [online]. 2014, vol.53, n.3, pp.254-265. ISSN 0034-7523.

Introduction: renal function may be estimated from serum creatinine or with prediction formulas. Hence the importance of being aware of the usefulness of these methods. Objective: determine the validity of serum creatinine and the reliability of renal function estimation formulas. Methods: a cross-sectional study was conducted of 6 290 patients with urolithiasis (4 133 male and 2 157 female -65.7% and 34.3 %, respectively-) undergoing metabolic studies at the Institute of Nephrology from 2006 to 2011. Data were processed with the statistical software SPSS version 15.0. ROC curves were used to evaluate the diagnostic capacity of serum creatinine. Reliability of the formulas was assessed with Bland-Altman plots. Results: the formulas with the smallest mean difference with respect to creatinine clearance were the following: for ERC (GFR ≤ 90 mL/min/1.73 m²): Cockcroft-Gault (3.81 mL/min/1.73 m²; DE 19.20 mL/min/1.73 m²), Salazar-Corcoran (-4.47 mL/min/1.73 m²; DE 18.40 mL/min/1.73 m²) and Levey (MDRD) (4.69 mL/min/1.73 m²; DE 13.75 mL/min/1.73 m²) and for IRC (GFR < 60 mL/min/1.73 m ²): Levey (MDRD) (1.39 mL/min/1.73 m²; DE 10.22 mL/min/1.73 m²), Jelliffe 1 973 (2.15 mL/min/1.73 m²; DE 10.87 mL/min/1.73 m²) and Salazar-Corcoran (-4.47 mL/min/1.73 m²; DE 18.40 mL/min/1.73 m²). The Baracskay formula showed the greatest mean difference (-9.67 mL/min/1.73m²; DE 17.04 mL/min/1.73 m²). Optimal cutoff value for serum creatinine in ERC was 1.07 mg/dL and 0.89 mg/dL for men and women, respectively. Conclusions: results suggest that the reliability of prediction formulas is high, except for Baracskay's, which is used in elderly patients.

Keywords : renal function; creatinine clearance; renal function prediction formulas.

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