Abstract

BACALLAO MENDEZ, Raymed Antonio et al. Renal metabolic disturbances in Cuban adult patients with urinary lithiasis. Rev cubana med [online]. 2014, vol.53, n.4, pp. 456-467. ISSN 0034-7523.

Introduction: the recurrence of urinary lithiasis is a health problem needing the implementation of preventive strategies, thus knowing the frequency of the different renal metabolic disorders is essential. Objectives: To identify the most common metabolic disorders in urinary lithiasic disease and their relationship with patient characteristics. Methods: an analytical, cross-sectional study was conducted in 3655 adult patients with urolithiasis. A renal metabolic study was conducted at the Institute of Nephrology from 2003 to 2009. The analytical determinations were performed by spectrophotometric technique according to the standards of service. All information is processed using SPSS version 15.0. The technique of frequency distribution analysis was used. Relationships between variables were identified by the test of independence. Results: The main metabolic disorders found were: hyperuricemia (48.2%), hypercalciuria (45.1%), and urinary tract infection (16.2 %). Hypercalciuria and hyperuricosuria were less frequent in subjects older than 42 years (p= 0.01). Hypercalciuria, hyperoxaluria and hyperuricosuria were more frequent in men (p= 0.00), while hypocitraturia was more frequent in women (p= 0.04). Hyperuricosuria was found more frequently in overweight and obese patients (p= 0.00), and hyperoxaluria was more frequent among overweight subjects (p= 0.01). Conclusions: In patients with renal lithiasis the most common metabolic disorders are hyperuricemia, hypercalciuria, and urinary tract infection. All subjects younger than 43 years suffered hypercalciuria and hyperuricosuria. Men have higher frequency of hypercalciuria, hyperuricosuria and hyperoxaluria. Women have higher frequency of hypocitraturia. The frequency of submission of hyperoxaluria, hyperuricosuria and hypocitraturia is related to the nutritional status of these subjects.

Keywords : urinary lithiasis; renal metabolic disturbance; urinary composition; hypercalciuria; hyperuricosuria.

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