Introduction:

Sickle cell anemia is a systemic pleiotropic disease. Almost all organs are affected with his condition. The forms of presentation of this disease vary.

Objective:

To describe the main characteristics of the most frequent complications and comorbidities in sickle cell anemia.

Method:

A literature review of articles published in the last 10 years on the most frequent complications and comorbidities in sickle cell anemia was carried out.

Conclusion:

The knowledge and differentiation of complications and comorbidities in sickle cell anemia allows the administration of appropriate therapies.

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