Abstract

ALINO SANTIAGO, Miriam; LOPEZ ESQUIROL, Juana; NAVARRO FERNANDEZ, Raymundo  and  DUPERVAL MALETA, Pablo. Aminoglycosides: a present look based on their history. Rev Cubana Pediatr [online]. 2007, vol.79, n.2, pp. 0-0. ISSN 1561-3119.

We referred to history, mechanisms of action and efficacy of aminoglycosides in pediatric patients as well as limitations in their use because of the emergence of bacterial resistance caused by overuse. The one-dose administration strategy as an alternative to the traditional methods of fractioned doses, the most frequent and serious complictions of aminoglycosides and their sinergism with other antimicrobial families were presented. We quoted research studies on antibiotic therapy made in the country.

Keywords : aminoglycosides; efficacy; one-dose; resistance; toxicity; synergism; monotherapy; combined therapy.

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