Abstract

ROIG ALVAREZ, Tania; MARTINEZ ENRIQUEZ, Addis; SANTURIO GIL, Antonio  and  FERNANDEZ RODRIGUE, Ana Julia. Prognostic value of some clinical laboratory examinations related to an early bacterial neonatal infection. Rev Cubana Pediatr [online]. 2009, vol.81, n.2, pp. 0-0. ISSN 1561-3119.

INTRODUCTION: Microbiological diagnosis of neonatal infection of early onset is complex. In most of newborns diagnosis is started if there is a clinical suspicion and the positivity of some acute-phase reactants and the hemogran. METHODS: Prognostic value was analyzed using as reference method the peripheral hemoculture or the pathological anatomy findings of infection in some of clinical laboratory examinations in an isolated way. Study was performed in all the cases, in 32 neonates presenting with a proven and probable early onset infection, and by infection localization. RESULTS: Neither positive reactive C protein nor total white cells alterations were good predictors of an early onset sepsis of any localization. Thrombocytopenia was a significant marker but not to estimate the 95%-confidence index (CI). In the exclusion of pulmonary localization, the positive reactive C protein became a significant marker. In none of neonates presenting a proven pulmonary infection it had positive results in clinical examinations performed. CONCLUSIONS: For the moment is not available a laboratory test able to predict with accuracy the presence of an early onset infection of any localization. Qualitative reactive C protein is a significant marker of an early infection of bloodstream and the meninges in neonates.

Keywords : Early neonatal infection; sepsis markers; diagnosis; neonatal sepsis.

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