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Revista Cubana de Pediatría

On-line version ISSN 1561-3119


ACOSTA TORRES, José Ramón; PEREZ CUTINO, Maite; RIVERA KEELING, Carlos  and  RODRIGUEZ PRIETO, Magela. Vascular thrombosis in pediatric patients affected by COVID-19. Rev Cubana Pediatr [online]. 2022, vol.94, suppl.1  Epub Dec 15, 2022. ISSN 1561-3119.


The disease by the new coronavirus caused a pandemic with an impact on children's health, which made clear the relationship between a state of inflammation, hypercoagulability and vascular thrombosis as the genesis of acute respiratory failure.


To describe the epidemiology of vascular thrombosis in pediatrics and to summarize the main available evidence related to the interaction between hyperinflammation, immune dysregulation, hypercoagulability and thrombosis.


Between December 2019 and June 2021, an orderly review of the medical databases PubMed and Google Scholar was carried out, in which the terms of the titles (MeSH) were used: "SARS-CoV-2 and Covid-19"; "coronavirus" and "infection"; "sepsis" and "Covid-19" and "Multisystem inflammatory syndrome in children" and "MIS-C and "PIMS-TS".

Analysis and synthesis of information:

Vascular thrombosis in pediatrics occurs between 1.2 and 26%, generated by inflammatory processes that lead to endothelitis with alterations of microvascular structures and thrombus formation. There are risk factors such as age≥ 12 years, mechanical ventilation, deep venous approach, presence of multisystem inflammatory syndrome, obesity and cancer. The diagnosis is supported by specific analyzes, especially the D-dimer, ultrasound with Dopplers and tomography. Anticoagulant treatment has not been unified and will depend on the protocols indicated in each country.


Vascular thrombosis in pediatrics, although infrequent, should be kept in mind to detect its presence in severe patients with risk factors and act accordingly with established protocols.

Keywords : COVID-19; vascular thrombosis; SIM-P; D-dimer; cytokines.

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