Abstract

GUTIERREZ MAYDATA, Alfredo; HANSJURGER, Köhle  and  PEREZ GONZALEZ, Orlando. Prenatal diagnosis in maternal blood cells: from imagination to reality. Rev Cubana Obstet Ginecol [online]. 1996, vol.22, n.2, pp. 0-0. ISSN 1561-3062.

The advances obtained in the cell separation techniques and in those of mollecular genetics, allow us to glimpse the possibility of making a prenatal diagnosis of genetic diseases in fetal cells obtained from maternal blood, as an alternative to present procedures that require intrauterine instrumentation and imply a risk, both for the mother and the fetus. The cytogenetic study of fetal cells combined with the use of monoclonal antibodies and procedures such as flow cytometry, cell separation by immunomagnetic microspheres, PCR and hydration in situ, are some of the present methods used as part of this increasing investigative effort, which will contribute to extend the benefits of prenatal diagnosis to the majority of the population in a near future.

Keywords : ERYTROCYTES [pathology]; GENETIC MARKERS; FLOW CYTOMETRY [methods]; CELL SEPARATION [methods]; PRENATAL DIAGNOSIS [methods]; CYTOGENETIC; FETUS [cytology].