Abstract

VELASCO BOZA, Alejandro et al. Efficacy of Misoprostol in the interruption of the 2nd trimester of pregnancy. Rev Cubana Obstet Ginecol [online]. 2008, vol.34, n.3. ISSN 0138-600X.

OBJECTIVE: to evaluate the efficacy, safety and acceptance of the vaginal administration of Misoprostol tablets 400 µg up to a maximum of 3 doses in a period of 24 hours (one every 8 hours) to induce abortion between 13 and 15 weeks of gestation, and 200 µg of Misoprostol in the same way for pregnancies from 16 to 20 weeks. METHODS: a clinical, descriptive and prospective study was carried out in "América Arias" Hospital with a universe of 470 patients that visited the family planning department of the center to request pregnancy interruption. Of them, a sample of 189 was selected that fulfilled the inclusion criteria and gave their consent to participate in the research. RESULTS: The method was considered efficient when it provoked a complete abortion and no surgical procedures were necessary. There was a prevalence of females aged 20-30 (51.8 %), 58.7 % of them were single, 41.3 % had preuniversity level, 36.0 % were black, parity was 55 % and 51.8 % had no previous abortions. The most significant secondary effects were chills (47.6 %), nausea (28.5 %), pelvic pain (27.5 %) and uterine bleeding higher than the menstrual (45.5 %). The highest effectivity was attained with the second dose used in both groups. Success was achieved in 92.6 % of the cases. There were 14 fails: 3 due decision of the patients, 3 were failed abortions and 8 were failures of the method that in all account for 7.4 %. CONCLUSIONS: According to the results it may be affirmed that the dose used of Misoprostol every 8 hours is a valid method to interrupt pregnancy between 13 and 20 weeks

Keywords : Misoprostol; therapeutic use; induced abortion; methods.

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