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Revista Cubana de Obstetricia y Ginecología

Print version ISSN 0138-600X


VELASQUEZ BERRIO, Manuela; GIL-VILLA, Aura María  and  CADAVID JARAMILLO, Angela Patricia. Aspirin induced lipoxins: alternative to modulate proinflammatory processes in preeclampsia. Rev Cubana Obstet Ginecol [online]. 2013, vol.39, n.3, pp. 292-305. ISSN 0138-600X.

Preeclampsia is a hypertensive syndrome that occurs after the 20th weeks of gestation. The objective of this review was to describe the mechanisms of production and action of aspirin- triggered lipoxins in order to consider them as a suitable alternative to modulate oxidative processes, which are characteristic of preeclampsia and proinflammatory cycles starting with cascade activation of nuclear factor-kappa B, consequently of their products. Preeclampsia is characterized by the production of proinflammatory substances that induce directly or indirectly endothelial cell activation,, through prior activation of monocytes, which can generate reactive oxygen species and expression of adhesion molecules that mediate interacting with the endothelium, contributing to its dysfunction, activation and induction of signaling cascade nuclear factor-kappa B. Aspirin induces lipoxin, which inhibits the activation of nuclear factor-kappa B by blocking IkB protein kinase, necessary to trigger the activation of canonical and non-canonical pathway of this nuclear factor.

Keywords : preeclampsia; endothelial dysfunction; nuclear factor-kappa B; aspirin-triggered lipoxins.

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