Abstract

FRONTELA NODA, Maydelín; RODRIGUEZ MARIN, Yoima; RIOS HERNANDEZ, María de los Ángeles  and  HERNANDEZ MENENDEZ, Maite. Chlamydia trachomatis. Rev Cubana Obstet Ginecol [online]. 2014, vol.40, n.1, pp.68-78. ISSN 0138-600X.

It has been shown that human papillomavirus presence is a necessary condition for the development of cervical cancer. However, it is not sufficient and only a small number of exposed women will progress to cervical neoplasia. Proposed cofactors include other sexually transmitted infections, smoking habit, hormones, nutritional deficiencies, obesity and host genetic/immunologic responses. Chlamydia trachomatis is the most common bacterial sexually transmitted infection and it has been associated with the development of cervical cancer in many case-controlled and population based studies. However, it is still necessary to elucidate some aspects of cause/effect relationship between Chlamydia trachomatis infection, human papillomavirus persistence and progression to cervical cancer. This article aims to review the current scientific literature upon the role of Chlamydia trachomatis as a cofactor in the development of invasive cervical cancer and HPV establishment. Prophylaxis against Chlamydia trachomatis could be important in reducing the incidence of cervical cancer, mainly in young women.

Keywords : Chlamydia trachomatis; cervical cancer; human papillomavirus (HPV).

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