Abstract

ABREU UGARTE, Jorge Eduardo; CRUZ GARCIA, María Antonia; CRUZ MOJARRIETA, Julia  and  RODRIGUEZ OBAYA, Teresita. Expression of HLA-DR1 antigen in skin carcinomas and its relation with T-Lymphocytes. Rev Cub Med Mil [online]. 1997, vol.26, n.1, pp. 30-37. ISSN 1561-3046.

An immune-histo-enzymatic method with IOR monoclonal antibodies was used to study in situ the expression of the HLA-DR1 antigen in the inflammatory infiltrate of skin carcinomas, and to relate it with the presence of T-lymphocyted in such infiltrate. Cases were classified according to the pathological anatomy report in 50 basal cell carcinomas, and 30 epidermoids. There was no significant difference in the HLA-DR1 expression when comparing both carcinomas. A relation was found between the amount of cells expressing HLA-DR1, and of CD6+, CD3+, and CD2+ T-lymphocytes in both tumors, and the CD4+ subpopulation in the epidermoid. The number of CD8+ was scarce in all cases.

Keywords : SKIN NEOPLASMS [immunology]; T-LYMPHOCYTES; CARCINOMA, BASAL CELL [immunology]; CARCINOMA, SQUAMOUS CELL [immunology]; TUMOR MARKERS, BIOLOGICAL; HLA-DR1 ANTIGEN; ANTIBODIES, MONOCLONAL.